Understanding how RSV changes the body's defenses
Mechanisms of Host Response Modulation by RSV Non-Structural Proteins
This research explores how the RSV virus tricks our bodies to cause severe airway infections, hoping to find new ways to protect us.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11122365 on NIH RePORTER |
What this research studies
Respiratory Syncytial Virus (RSV) causes serious breathing problems, especially in children, older adults, and those with weakened immune systems, yet we have few good treatments or ways to prevent it. This project focuses on two unique RSV proteins, NS1 and NS2, which seem to help the virus spread and avoid our immune system. We want to understand exactly how these proteins change our body's cells and their defenses. By uncovering these hidden mechanisms, we hope to pave the way for better ways to fight RSV infections.
Who could benefit from this research
Good fit: This foundational research aims to ultimately benefit anyone susceptible to severe RSV infections, including infants, young children, the elderly, and individuals with compromised immune systems.
Not a fit: Patients who do not have RSV or are not at risk for severe airway infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new medications or vaccines that specifically target how RSV manipulates our immune system, offering better protection and treatment options.
How similar studies have performed: This project builds upon novel preliminary findings from the research team, exploring previously unknown mechanisms of RSV's interaction with human cells.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Leung, Daisy W — Washington University
- Study coordinator: Leung, Daisy W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.