Understanding how Rous sarcoma virus integrates its DNA into host cells.
Official title: Assembly mechanisms of Rous sarcoma virus intasomes.
Funded at Saint Louis University · NIH-11074982 · Data updated 2026-11-12
This study is looking at how a virus called Rous sarcoma virus puts together its important proteins to help it insert its DNA into the DNA of host cells, which could help scientists find new ways to fight viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Saint Louis University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 3, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $462,982 |
| NIH project number | 1R56AI175583-01A1 |
| Project ID | NIH-11074982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals affected by retroviral infections, such as those with Human T-Cell Leukemia Virus.
✕Less likely to help
Patients with non-retroviral infections or those not affected by viral diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the Rous sarcoma virus assembles its integrase multimers, which are crucial for integrating viral DNA into the DNA of host cells. By using advanced techniques like cryo-electron microscopy, the study aims to reveal the structural details of these viral complexes and how they function. The research will explore the assembly of different forms of the virus's integrase and how these structures contribute to the viral integration process. This knowledge could lead to new strategies for targeting viral infections.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies for viral infections, particularly those caused by retroviruses.
How similar studies have gone: Other research has shown success in understanding viral integration mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Saint Louis University
Saint Louis, United States Active
Researchers
- Principal investigator: Pandey, Krishan Kumar — Saint Louis University
- Study coordinator: Pandey, Krishan Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.