Understanding how rotaviruses infect cells and cause illness in children
Official title: Rotavirus Reverse Genetics System to Study Viral Pathogenesis and Receptor Interactions
Funded at Ohio State University · NIH-10885190 · Data updated 2026-11-12
This study is looking at how rotaviruses, which can make young kids sick with stomach bugs, get into and multiply in our cells, so we can find better ways to prevent and treat these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 10, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $236,250 |
| NIH project number | 5R21AI173880-02 |
| Project ID | NIH-10885190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under the age of 11 who are at risk for rotavirus infections or have experienced gastroenteritis.
✕Less likely to help
Patients who are older than 11 years or those who have not been affected by rotavirus infections may not benefit from this research.
What this research studies
This research investigates the mechanisms by which rotaviruses, a leading cause of gastroenteritis in young children, enter and replicate within host cells. By using a specialized cell culture system, the researchers aim to identify specific genetic changes in the virus that affect its ability to cause disease. The study focuses on understanding how these viruses interact with cell surface molecules, which could lead to better prevention and treatment strategies for rotavirus infections in children.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for rotavirus infections, reducing illness and mortality in young children.
How similar studies have gone: Previous research has shown promise in understanding rotavirus interactions with host cells, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Vlasova, Anastasia Nickolaevna — Ohio State University
- Study coordinator: Vlasova, Anastasia Nickolaevna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.