Understanding how rotavirus enters intestinal cells
Official title: Mechanism of Rotavirus Entry
Funded at Washington University · NIH-10908289 · Data updated 2026-11-12
This study is looking at how the rotavirus, which causes bad diarrhea in kids, gets into their gut cells, and by understanding this better, we hope to find new ways to prevent and treat infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21AI168490-02 |
| Project ID | NIH-10908289 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are children under 11 years old who are at risk for rotavirus infections.
✕Less likely to help
Patients who are older than 11 years or those who have already been vaccinated against rotavirus may not receive benefit from this research.
What this research studies
This research investigates the mechanisms by which rotavirus, a leading cause of severe diarrhea in children, enters human intestinal cells. By utilizing advanced techniques such as CRISPR gene editing and proteomic analysis, the study aims to identify host proteins that facilitate viral entry. The findings could lead to the development of new antiviral strategies and improved vaccines. Patients may benefit from insights that could enhance prevention and treatment options for rotavirus infections.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for rotavirus infections in children.
How similar studies have gone: Other research has shown success in identifying viral entry mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Ding, Siyuan — Washington University
- Study coordinator: Ding, Siyuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.