Understanding how rotavirus affects calcium signaling in children
Dissecting Rotavirus Viroporin and Enterotoxin Calcium Signaling Pathways
This study is looking at how rotavirus affects calcium signals in young children, especially those under 5, to help us understand why it can cause severe diarrhea and find better ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10906840 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which rotavirus infection disrupts calcium signaling in children, particularly those under 5 years old. By using advanced live imaging techniques, the study aims to identify specific calcium signaling events that occur during rotavirus infection, which may contribute to severe diarrheal diseases. The research focuses on the role of a viral protein, NSP4, in causing these disruptions and how it affects both infected and surrounding cells. The findings could lead to better understanding and treatment options for pediatric diarrheal diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 5 years old who are experiencing rotavirus infections or related diarrheal diseases.
Not a fit: Patients over the age of 5 or those not infected with rotavirus may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for rotavirus infections, potentially reducing mortality and morbidity in young children.
How similar studies have performed: Previous research on rotavirus and calcium signaling has shown promising results, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Hyser, Joseph M. — Baylor College of Medicine
- Study coordinator: Hyser, Joseph M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.