Understanding How RNA Works in Our Genes
RNA-based mechanisms in nuclear steps of gene expression
This research explores how RNA molecules control our genes, aiming to understand why problems with RNA can lead to conditions like ALS and blindness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11136254 on NIH RePORTER |
What this research studies
Our bodies rely on RNA molecules to carry out essential steps in how our genes work, and when these RNA interactions go wrong due to inherited changes, they can cause age-related problems in the eyes, brain, and nerves. This project uses baker's yeast as a model to uncover the basic ways RNA and proteins interact in healthy cells. By understanding these fundamental processes, we hope to learn why specific defects lead to severe conditions like progressive blindness and neurodegenerative diseases.
Who could benefit from this research
Good fit: Patients with inherited forms of conditions such as Amyotrophic Lateral Sclerosis (ALS), frontotemporal degeneration, or retinitis pigmentosa might find this basic research relevant to their conditions.
Not a fit: Patients whose conditions are not related to inherited RNA defects in gene expression may not directly benefit from this specific research.
Why it matters
Potential benefit: This work could lead to new ways to understand and potentially treat inherited conditions affecting the brain and eyes by clarifying their underlying molecular causes.
How similar studies have performed: This foundational research builds upon existing knowledge of gene expression but explores specific RNA mechanisms and disease links in a novel way.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Brow, David a — University of Wisconsin-Madison
- Study coordinator: Brow, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.