Understanding how RNA viruses assemble and disassemble their protective shells
Official title: Direct measurements of RNA virus nucleocapsid self-assembly and disassembly
Funded at San Diego State University · NIH-11022517 · Data updated 2026-11-12
This study is looking at how certain viruses put themselves together and break apart, which is important for their reproduction, and it's aimed at helping scientists find new ways to treat viral infections and improve genetic medicine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | May 10, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $370,190 |
| NIH project number | 1R35GM157105-01 |
| Project ID | NIH-11022517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by RNA virus infections, such as those with viral diseases that currently lack effective treatments.
✕Less likely to help
Patients with non-viral infections or those not affected by RNA viruses may not benefit from this research.
What this research studies
This research investigates the molecular processes involved in the self-assembly and disassembly of viral nucleocapsids, which are crucial for the replication of RNA viruses. Using advanced techniques like interferometric scattering microscopy and cryo-electron microscopy, the researchers aim to uncover universal mechanisms that govern these processes across different virus types. By focusing on the role of RNA sequence and structure, the study seeks to provide insights that could lead to the development of new antiviral therapies and innovative delivery systems for genetic medicine.
Why it matters
Potential benefit: If successful, this research could lead to the creation of new antiviral treatments that effectively stop the spread of RNA viruses.
How similar studies have gone: Previous research has shown promise in using similar methodologies to understand viral mechanisms, indicating a potential for success in this approach.
Where this research is happening
-
San Diego State University
San Diego, United States Active
Researchers
- Principal investigator: Garmann, Rees F — San Diego State University
- Study coordinator: Garmann, Rees F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.