Understanding how RNA structures regulate gene expression
Role of structural dynamics in RNA regulation
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10875601
This study is looking at how certain parts of RNA can affect how genes work and break down in our cells, which could help us understand more about diseases and how to treat them.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10875601 on ClinicalTrials.gov |
What this research studies
This research investigates the role of RNA structures, specifically in the 3' untranslated regions (3'UTRs) of messenger RNAs (mRNAs), in controlling gene expression and decay. By utilizing a novel technology called DANCE-MaP, the research aims to explore how these RNA structures can influence the binding of proteins and microRNAs, which are crucial for regulating gene activity. The study will focus on understanding the dynamic nature of these RNA structures in living cells, which could reveal new insights into their involvement in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases associated with disruptions in RNA regulation.
Not a fit: Patients with conditions unrelated to RNA regulation or those not affected by genetic mutations in mRNA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to RNA regulation.
How similar studies have performed: Other research has shown promising results in understanding RNA structures and their regulatory roles, suggesting that this approach could yield significant insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUSTOE, ANTHONY MCDOWELL — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MUSTOE, ANTHONY MCDOWELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease