Understanding how RNA structures change to regulate cell activity
Structural dynamics of regulatory RNAs and ribonucleoproteins
['FUNDING_OTHER'] · UNIVERSITY OF NEBRASKA LINCOLN · NIH-10891631
This study is looking at how RNA and its partner proteins change shape to do their jobs in our cells, which can help us understand how these processes work normally and what goes wrong in diseases like cancer and heart disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA LINCOLN (nih funded) |
| Locations | 1 site (LINCOLN, UNITED STATES) |
| Trial ID | NIH-10891631 on ClinicalTrials.gov |
What this research studies
This research investigates the structural dynamics of RNA and its associated proteins, focusing on how these molecules adapt and change shape to perform their functions in cells. By using advanced techniques like NMR spectroscopy and X-ray crystallography, the research aims to uncover the mechanisms behind RNA folding and its interactions with other molecules. This knowledge is crucial for understanding normal cellular processes and how these processes can be disrupted in diseases such as cancer and heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by genetic diseases such as cancers, heart disease, or primordial dwarfism.
Not a fit: Patients with conditions unrelated to RNA dysregulation or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases linked to RNA dysfunction, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding RNA dynamics and its implications in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
LINCOLN, UNITED STATES
- UNIVERSITY OF NEBRASKA LINCOLN — LINCOLN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EICHHORN, CATHERINE — UNIVERSITY OF NEBRASKA LINCOLN
- Study coordinator: EICHHORN, CATHERINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.