Understanding how RNA structures and interacts with proteins
Mapping the sequence landscape of RNA structure, dynamics and protein interactions using high-throughput single-molecule FRET
This study is looking at how RNA, a key part of our cells, shapes itself and interacts with other molecules, which could help us understand its role in gene expression and diseases, and it's designed for anyone interested in the science behind how our bodies work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-10900592 on NIH RePORTER |
What this research studies
This research investigates the complex roles of RNA in biological processes, focusing on how RNA folds into specific structures that influence its interactions with proteins and other molecules. By utilizing advanced spectroscopic techniques, including single-molecule and ultrafast spectroscopy, the team aims to capture the dynamic behavior of RNA and its interactions in real-time. The goal is to develop high-throughput methods to study these interactions, which could lead to new insights into RNA's role in gene expression and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that involve RNA processing or regulation.
Not a fit: Patients with conditions unrelated to RNA function or those not affected by genetic alterations in RNA are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of RNA functions and lead to novel therapeutic strategies for diseases linked to RNA dysfunction.
How similar studies have performed: Previous research has shown promising results using single-molecule techniques to study RNA interactions, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Widom, Julia Reed — University of Oregon
- Study coordinator: Widom, Julia Reed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.