Understanding how RNA splicing works in health and disease
Illuminating multiplexed RNA dynamics to interrogate splicing in health and disease
This study is looking at how our cells make the right instructions for building proteins, which is really important for our health, and it aims to understand how changes in our genes or stress on our cells can mess up this process, with the hope that it can help develop new treatments for conditions like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11087695 on NIH RePORTER |
What this research studies
This research investigates the complex process of RNA splicing, which is crucial for producing the correct messenger RNA (mRNA) needed for protein synthesis. By using advanced fluorescence microscopy techniques, the study aims to visualize and analyze the dynamics of RNA splicing in real-time within cells. The research focuses on how genetic mutations and environmental stressors can disrupt this process, potentially leading to diseases such as cancer and neurological disorders. Patients may benefit from insights gained about RNA splicing mechanisms that could inform new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates include individuals with genetic mutations or conditions associated with alternative RNA splicing, such as certain cancers or neurological disorders.
Not a fit: Patients without genetic mutations or those not affected by diseases related to RNA splicing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to RNA splicing errors.
How similar studies have performed: Other research has shown promising results in understanding RNA dynamics and splicing, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Braselmann, Esther — Georgetown University
- Study coordinator: Braselmann, Esther
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.