Understanding how RNA splicing affects health and disease
Official title: Computational genomics approaches to study mechanisms and function of mRNA splicing
Funded at University of Chicago · NIH-11141693 · Data updated 2026-11-12
This study is looking at how our genes are put together and how that affects our health, with the goal of finding new ways to treat diseases by understanding and changing the way RNA splicing works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 19, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $403,112 |
| NIH project number | 5R35GM153249-02 |
| Project ID | NIH-11141693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with genetic disorders or diseases where RNA splicing plays a critical role.
✕Less likely to help
Patients with conditions unrelated to RNA splicing mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms of RNA splicing and how it is encoded in DNA, aiming to improve human health through better treatment designs. By developing advanced computational methods and genomic assays, the project seeks to characterize the regulation of gene expression levels influenced by RNA splicing. Additionally, it will explore how small molecules can modulate RNA splicing, potentially leading to new therapeutic strategies. Patients may benefit from insights gained that could lead to innovative treatments for various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies targeting RNA splicing, improving treatment options for patients with genetic disorders and other diseases.
How similar studies have gone: Other research has shown promise in understanding RNA splicing and its implications for disease, indicating that this approach could yield significant insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Li, Yang — University of Chicago
- Study coordinator: Li, Yang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.