Understanding how RNA splicing affects health and disease
Computational genomics approaches to study mechanisms and function of mRNA splicing
This study is looking at how our genes are put together and how that affects our health, with the goal of finding new ways to treat diseases by understanding and changing the way RNA splicing works.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11141693 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of RNA splicing and how it is encoded in DNA, aiming to improve human health through better treatment designs. By developing advanced computational methods and genomic assays, the project seeks to characterize the regulation of gene expression levels influenced by RNA splicing. Additionally, it will explore how small molecules can modulate RNA splicing, potentially leading to new therapeutic strategies. Patients may benefit from insights gained that could lead to innovative treatments for various diseases.
Who could benefit from this research
Good fit: Ideal candidates include individuals with genetic disorders or diseases where RNA splicing plays a critical role.
Not a fit: Patients with conditions unrelated to RNA splicing mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies targeting RNA splicing, improving treatment options for patients with genetic disorders and other diseases.
How similar studies have performed: Other research has shown promise in understanding RNA splicing and its implications for disease, indicating that this approach could yield significant insights.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Li, Yang — University of Chicago
- Study coordinator: Li, Yang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.