Understanding how RNA splicing affects breast cancer spread
The RNA structural code underlying pathological regulation of RNA splicing in metastasis
This study is looking at how a specific process in our cells, called RNA splicing, might play a role in the growth of aggressive breast cancer, and it's for anyone interested in understanding how this could help improve treatments and outcomes for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10857318 on NIH RePORTER |
What this research studies
This research investigates the complex mechanisms of RNA splicing and how it contributes to the progression of breast cancer. By utilizing advanced computational methods, the team aims to identify both known and novel regulatory elements that influence RNA processing. The study focuses on a newly discovered RNA structural splicing enhancer that has been linked to aggressive forms of breast cancer. Through experiments in mouse models, the researchers are exploring how this splicing mechanism affects tumor growth and patient survival.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic breast cancer who may benefit from targeted therapies based on RNA splicing mechanisms.
Not a fit: Patients with early-stage breast cancer or those whose cancer is not related to RNA splicing abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating metastatic breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding RNA splicing in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Goodarzi, Hani — University of California, San Francisco
- Study coordinator: Goodarzi, Hani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.