Understanding how RNA regulatory elements function
Large-scale characterization of the function of RNA regulatory elements
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10895584
This study is looking at how certain proteins and RNA molecules work together to manage the way RNA is processed in our bodies, which could help us understand and find new treatments for diseases related to RNA.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10895584 on ClinicalTrials.gov |
What this research studies
This research investigates the role of RNA binding proteins and regulatory RNAs in controlling RNA processing, including its sequence, stability, and translation. By utilizing advanced genomic techniques, the study aims to identify functional RNA regulatory elements from a vast catalog of interaction sites. The goal is to determine how variations in these elements may affect RNA biology and contribute to diseases. This could lead to better understanding and potential treatments for conditions influenced by RNA processing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations that may impact RNA processing, particularly those affected by conditions like Spinal Muscular Atrophy.
Not a fit: Patients with conditions unrelated to RNA processing or those without genetic variations affecting RNA biology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of RNA biology and lead to new therapeutic strategies for diseases related to RNA processing.
How similar studies have performed: Other research has shown success in identifying RNA regulatory elements, but this approach aims to fill a significant knowledge gap, making it a novel effort.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN NOSTRAND, ERIC LYMAN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: VAN NOSTRAND, ERIC LYMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aran-Duchenne disease, Cruveilhier disease