Understanding how RNA regulation affects individual cells and tissues
Dissecting RNA regulation in single cells and tissues
This study is looking at how certain proteins that help manage RNA in our cells might be linked to diseases like ALS and FTD, and it aims to understand how changes in these proteins can affect different types of cells, which could help us learn more about these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project ID | NIH-11103406 on NIH RePORTER |
What this research studies
This research investigates the role of RNA Binding Proteins (RBPs) in regulating RNA processing, which is crucial for the function of individual cells and tissues. It aims to uncover why mutations in widely-expressed RBPs lead to specific diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD). By focusing on two model RBPs, MEC-8/RBPMS and SMN-1, the research will explore how these proteins influence cell-specific outcomes and identify the targets responsible for these effects. This could provide insights into the mechanisms underlying various diseases linked to RNA dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Amyotrophic Lateral Sclerosis or Frontotemporal Degeneration.
Not a fit: Patients with conditions unrelated to RNA regulation or those not diagnosed with ALS or FTD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases like ALS and FTD by targeting RNA regulation.
How similar studies have performed: Previous research has shown promising results in understanding RNA regulation in other diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Riverside, United States
- University of California Riverside — Riverside, United States (Active)
Researchers
- Principal investigator: Norris, Adam — University of California Riverside
- Study coordinator: Norris, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.