Understanding how RNA regulation affects cell behavior and disease progression
Official title: Dynamics of RNA regulation and noncanonical translation between cell states
Funded at University of Pennsylvania · NIH-10939861 · Data updated 2026-11-12
This study looks at how changes in RNA affect the production of proteins in cells, especially when it comes to diseases, to help find better treatment options that match individual patients' needs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $406,250 |
| NIH project number | 1R35GM154896-01 |
| Project ID | NIH-10939861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with genetic disorders or cancers where RNA regulation plays a significant role in disease progression.
✕Less likely to help
Patients with conditions unrelated to RNA regulation or those who do not have genetic components to their disease may not benefit from this research.
What this research studies
This research investigates the complex relationship between RNA regulation and protein synthesis in cells, particularly in the context of disease. By analyzing chromosomal rearrangements and RNA abundance, the project aims to uncover discrepancies between RNA levels and protein production, which can impact treatment strategies. The study focuses on how certain mRNAs are translated in response to disease, potentially leading to new therapeutic approaches tailored to specific conditions. Patients may benefit from insights into how their genetic expression influences disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostic tools and targeted therapies for various diseases.
How similar studies have gone: Other research has shown promising results in understanding RNA regulation and its implications for disease, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Conn, Crystal S — University of Pennsylvania
- Study coordinator: Conn, Crystal S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.