Understanding how RNA processing affects early B-cell development
Investigating the role of chromatin-associated RNA processing in Early B-cell development
['FUNDING_FELLOWSHIP'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11071146
This study is looking at how a process called RNA processing helps B-cells, which are important for our immune system, develop properly and create a variety of antibodies, and the findings could help improve our understanding of immune responses for patients.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11071146 on ClinicalTrials.gov |
What this research studies
This research investigates the role of RNA processing in the development of B-cells, which are crucial for the immune system. It focuses on a specific genetic rearrangement process called VDJ recombination that allows B-cells to produce diverse antibodies. Using innovative mouse models and in-vitro systems, the study aims to uncover the mechanisms by which RNA processing influences this genetic rearrangement and ensures the stability of the B-cell genome. Patients may benefit from insights gained into B-cell development and its implications for immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with immune system disorders or those interested in the genetic basis of B-cell development.
Not a fit: Patients with conditions unrelated to B-cell development or those not affected by immune system disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immune system development and potential therapies for immune-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of B-cell development and VDJ recombination, indicating that this approach has potential for significant findings.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHISENANT, DANIEL ERIC — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: WHISENANT, DANIEL ERIC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.