Understanding how RNA processing affects early B-cell development
Official title: Investigating the role of chromatin-associated RNA processing in Early B-cell development
Funded at Columbia University Health Sciences · NIH-11071146 · Data updated 2026-11-12
This study is looking at how a process called RNA processing helps B-cells, which are important for our immune system, develop properly and create a variety of antibodies, and the findings could help improve our understanding of immune responses for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI188882-01 |
| Project ID | NIH-11071146 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with immune system disorders or those interested in the genetic basis of B-cell development.
✕Less likely to help
Patients with conditions unrelated to B-cell development or those not affected by immune system disorders may not receive any benefit from this research.
What this research studies
This research investigates the role of RNA processing in the development of B-cells, which are crucial for the immune system. It focuses on a specific genetic rearrangement process called VDJ recombination that allows B-cells to produce diverse antibodies. Using innovative mouse models and in-vitro systems, the study aims to uncover the mechanisms by which RNA processing influences this genetic rearrangement and ensures the stability of the B-cell genome. Patients may benefit from insights gained into B-cell development and its implications for immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immune system development and potential therapies for immune-related disorders.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of B-cell development and VDJ recombination, indicating that this approach has potential for significant findings.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Whisenant, Daniel Eric — Columbia University Health Sciences
- Study coordinator: Whisenant, Daniel Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.