Understanding how RNA polymerase interacts with regulatory factors during gene transcription
Official title: Structural study of direct associations between cellular RNA polymerase and regulatory factors during the transcription cycle
Funded at Pennsylvania State University, the · NIH-11011797 · Data updated 2026-11-12
This study is looking at how a special enzyme called RNA polymerase works with other molecules to help turn genes on and off in bacteria and archaea, which could help us understand more about gene expression and its role in different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $451,802 |
| NIH project number | 1R35GM156623-01 |
| Project ID | NIH-11011797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or conditions that may be influenced by transcriptional regulation.
✕Less likely to help
Patients with conditions unrelated to transcriptional regulation or those not affected by genetic factors may not receive benefit from this research.
What this research studies
This research investigates the structural dynamics of RNA polymerase, a key enzyme in gene expression, and its interactions with various regulatory factors. Using advanced techniques like cryo-electron microscopy and single-molecule approaches, the study aims to uncover the complexities of transcription processes in bacteria and archaea. By analyzing the different states of transcription complexes, the research seeks to provide insights into how gene expression is regulated at a molecular level, which could have implications for understanding various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, potentially benefiting patients with genetic disorders or diseases linked to transcriptional regulation.
How similar studies have gone: Previous research using similar structural biology techniques has shown success in elucidating complex biological processes, suggesting that this approach could yield valuable insights as well.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Murakami, Katsuhiko — Pennsylvania State University, the
- Study coordinator: Murakami, Katsuhiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.