Understanding how RNA polymerase I works and its role in cancer and developmental disorders
New Paradigms for the molecular basis of RNA polymerase I transcription
This study is looking at how a special enzyme called RNA polymerase I helps make a vital part of our cells, which is important for growth and health, and it hopes to find out how problems with this enzyme might be linked to cancer and other health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11068622 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms of RNA polymerase I (Pol I), which is responsible for transcribing ribosomal RNA, a crucial component of ribosomes. By examining how Pol I interacts with DNA and its associated factors, the research aims to uncover the differences between Pol I and other RNA polymerases, which could lead to insights into how dysregulation of Pol I contributes to cancer and developmental disorders. The approach includes studying the structural organization of Pol I complexes and the molecular functions of key transcription factors involved in the activation process. This work is essential for understanding the fundamental processes of gene expression and their implications for human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or developmental disorders linked to RNA polymerase I dysregulation.
Not a fit: Patients with conditions unrelated to RNA polymerase I function or those not affected by cancer or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer treatment and developmental disorder management by targeting the mechanisms of RNA polymerase I.
How similar studies have performed: While the specific mechanisms of RNA polymerase I are less studied, research into other RNA polymerases has shown promising results, indicating potential for breakthroughs in understanding Pol I.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Knutson, Bruce Alan — Upstate Medical University
- Study coordinator: Knutson, Bruce Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.