Understanding how RNA polymerase I works and its role in cancer and developmental disorders
New Paradigms for the molecular basis of RNA polymerase I transcription
['FUNDING_R01'] · UPSTATE MEDICAL UNIVERSITY · NIH-11044987
This study is looking at how a special enzyme called RNA polymerase I helps make a key part of our cells, and it aims to understand how problems with this process can lead to cancer and other health issues, which could eventually help patients by revealing new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UPSTATE MEDICAL UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-11044987 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms of RNA polymerase I (Pol I), which is responsible for producing ribosomal RNA, a crucial component of ribosomes. By exploring how Pol I transcription is regulated and how its dysregulation can lead to cancer and developmental disorders, the study aims to fill significant gaps in our understanding of this process. The research will involve detailed biochemical and biophysical analyses to uncover the structural organization of Pol I transcription complexes and the interactions of initiation factors with ribosomal DNA. Patients may benefit from insights gained into how Pol I defects contribute to disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or developmental disorders that may be associated with RNA polymerase I dysregulation.
Not a fit: Patients with conditions unrelated to RNA polymerase I function or those not affected by cancer or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers and developmental disorders linked to RNA polymerase I dysregulation.
How similar studies have performed: While the specific mechanisms of RNA polymerase I are less studied, there is a growing body of research indicating that understanding transcription mechanisms can lead to significant advancements in cancer treatment.
Where this research is happening
SYRACUSE, UNITED STATES
- UPSTATE MEDICAL UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KNUTSON, BRUCE ALAN — UPSTATE MEDICAL UNIVERSITY
- Study coordinator: KNUTSON, BRUCE ALAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.