Understanding how RNA modifications affect protein production in cells
Biogenesis of macromolecular machines for post-transcriptional regulation of translation
['FUNDING_OTHER'] · EMORY UNIVERSITY · NIH-10892875
This study is looking at how certain changes in tiny RNA molecules can affect the production of ribosomes, which are crucial for making proteins in our cells, and it hopes to find new ways to help people with diseases like cancer and neurodegeneration that are linked to problems with ribosomes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10892875 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific RNA modifications in the production of ribosomes, which are essential for protein synthesis in all cells. It focuses on how alterations in small nucleolar RNAs (snoRNAs) can lead to defects in ribosome function and contribute to diseases such as neurodegeneration and cancer. By mapping these modifications, the research aims to uncover the mechanisms that regulate snoRNA levels and their impact on cellular growth and gene expression. Patients may benefit from insights that could lead to new treatments for conditions linked to ribosome dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to neurodegeneration or various cancers that may involve dysregulation of ribosome function.
Not a fit: Patients with conditions unrelated to ribosome function or snoRNA dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with ribosome dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown that understanding RNA modifications can lead to significant advancements in treating diseases related to ribosome dysfunction, indicating a promising avenue for this investigation.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GHALEI, HOMA — EMORY UNIVERSITY
- Study coordinator: GHALEI, HOMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.