Understanding how RNA modifications affect HIV infection and treatment
Coupling Epitranscriptomics to Molecular Disease Mechanisms and Nucleic Acid Therapeutics in Persistent Residual HIV Infection
['FUNDING_OTHER'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-11311426
This study is looking at how changes in RNA might affect HIV in people who are on treatment, with the goal of finding new ways to improve their health and quality of life.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-11311426 on ClinicalTrials.gov |
What this research studies
This research investigates the persistent infection of HIV in individuals receiving combination anti-retroviral therapy (cART). It focuses on the role of RNA modifications in the biology of HIV and how these modifications can influence the immune response and viral gene expression. By studying the interactions between cellular and viral RNA, the research aims to uncover new therapeutic strategies that could enhance the quality of life for people living with HIV. The approach involves advanced techniques in epitranscriptomics to manipulate RNA processes for potential treatment improvements.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on combination anti-retroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on anti-retroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the viral load and improve immune health for individuals living with HIV.
How similar studies have performed: Other research has shown promise in manipulating RNA modifications for therapeutic purposes, suggesting that this approach could yield significant advancements in HIV treatment.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAGNON, KEITH THOMAS — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: GAGNON, KEITH THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus