Understanding how RNA modifications affect gene expression
Center for Genomic Information Encoded by RNA Nucleotide Modifications
This study is looking at how tiny chemical changes in different types of RNA can affect how genes work in our cells, helping us understand more about how our bodies function and respond to diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10890608 on NIH RePORTER |
What this research studies
This research investigates the role of chemical modifications in different types of RNA, including rRNA, tRNA, and mRNA, and how these modifications influence gene expression in cells. By exploring the interactions between these RNAs and their modifications, the research aims to uncover a regulatory 'code' that controls gene expression patterns. The study employs advanced techniques to quantify and profile these nucleotide modifications, which are crucial for understanding cellular functions and responses in various tissues and disease states.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve dysregulated gene expression, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to RNA modifications or gene expression regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation, potentially informing treatments for diseases linked to RNA dysfunction.
How similar studies have performed: Other research has shown promising results in understanding RNA modifications and their impact on gene expression, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Jaffrey, Samie R — Weill Medical Coll of Cornell Univ
- Study coordinator: Jaffrey, Samie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.