Understanding how RNA modifications affect Alzheimer's disease progression
Epitranscriptomic Mechanism in pathogenesis of Alzheimer’s disease
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11053764
This study is looking at how changes in RNA might affect the buildup of tau protein in the brain, which is connected to Alzheimer's disease, and it hopes to find new ways to help treat or slow down the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11053764 on ClinicalTrials.gov |
What this research studies
This research investigates the role of RNA modifications in the development of Alzheimer's disease, particularly focusing on how these modifications relate to the aggregation of tau protein, which is linked to cognitive decline. By analyzing post-mortem brain samples and utilizing advanced molecular techniques, the study aims to uncover the mechanisms through which tau aggregation leads to neuronal toxicity and dysfunction. The goal is to identify potential new strategies for treating or modifying the course of Alzheimer's disease based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive decline associated with tau protein aggregation.
Not a fit: Patients with early-stage cognitive impairment not yet diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that slow down or alter the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA modifications in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIANG, LULU — UNIVERSITY OF VIRGINIA
- Study coordinator: JIANG, LULU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome