Understanding how RNA modifications affect Alzheimer's disease progression
Official title: Epitranscriptomic Mechanism in pathogenesis of Alzheimer’s disease
Funded at University of Virginia · NIH-11053764 · Data updated 2026-11-12
This study is looking at how changes in RNA might affect the buildup of tau protein in the brain, which is connected to Alzheimer's disease, and it hopes to find new ways to help treat or slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $745,092 |
| NIH project number | 1R01AG091577-01 |
| Project ID | NIH-11053764 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive decline associated with tau protein aggregation.
✕Less likely to help
Patients with early-stage cognitive impairment not yet diagnosed with Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of RNA modifications in the development of Alzheimer's disease, particularly focusing on how these modifications relate to the aggregation of tau protein, which is linked to cognitive decline. By analyzing post-mortem brain samples and utilizing advanced molecular techniques, the study aims to uncover the mechanisms through which tau aggregation leads to neuronal toxicity and dysfunction. The goal is to identify potential new strategies for treating or modifying the course of Alzheimer's disease based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that slow down or alter the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of RNA modifications in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Jiang, Lulu — University of Virginia
- Study coordinator: Jiang, Lulu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.