Understanding how RNA levels change in cells over time
Revealing the dynamics of RNA metabolism with nucleotide recoding chemistry
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10978974
This study is looking at how RNA levels change in healthy and sick cells, which could help us understand and treat diseases like Acute Megakaryoblastic Leukemia better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10978974 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic nature of RNA levels in both healthy and diseased cells, focusing on how various processes like transcription and degradation affect RNA metabolism. By developing new techniques that allow for the measurement of RNA changes over time, the research aims to provide insights into gene expression regulation. Patients may benefit from this work as it could lead to better understanding and treatment of diseases like Acute Megakaryoblastic Leukemia. The approach involves advanced nucleotide chemistry and open-source software to analyze RNA dynamics.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Acute Megakaryoblastic Leukemia or other related blood disorders.
Not a fit: Patients with conditions unrelated to RNA metabolism or those not diagnosed with blood disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with blood-related disorders.
How similar studies have performed: Other research has shown promise in using similar approaches to study RNA dynamics, indicating potential for success in this area.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMON, MATTHEW DAVID — YALE UNIVERSITY
- Study coordinator: SIMON, MATTHEW DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.