Understanding how RNA is organized in cells to improve treatments for diseases.
Official title: Manipulating and Interrogating Spatial Transcriptomics
Funded at Stanford University · NIH-10918110 · Data updated 2026-11-12
This study is looking at how the arrangement of mRNA in cells, especially in neurons and embryos, affects how proteins are made, which could help us understand diseases like ALS and lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,080,800 |
| NIH project number | 5DP1NS137219-02 |
| Project ID | NIH-10918110 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or related neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to RNA organization or those not diagnosed with the targeted diseases may not benefit from this research.
What this research studies
This research investigates the spatial organization of mRNA within cells, particularly in neurons and embryos, to understand how this affects protein synthesis and cellular function. By developing advanced technologies for tracking and manipulating the localization of mRNAs, the research aims to uncover the mechanisms behind spatial RNA organization and its implications for diseases like amyotrophic lateral sclerosis (ALS). Patients may benefit from insights gained through real-time RNA tracking and computational analysis, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases associated with abnormal RNA organization, such as ALS.
How similar studies have gone: Previous research has shown promising results in understanding RNA localization in various cell types, indicating potential for success in this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Qi, Lei Stanley — Stanford University
- Study coordinator: Qi, Lei Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.