Understanding how RNA is localized and regulated on the endoplasmic reticulum
Mechanisms of RNA localization and translational regulation on the endoplasmic reticulum
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10872124
This study is looking at how certain messages in our cells, called RNA, find their way to a part of the cell called the endoplasmic reticulum, where proteins are made, to help us understand how proteins are created and how our cells work better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10872124 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which RNA is localized and translated on the endoplasmic reticulum (ER), a crucial site for protein synthesis. It explores how various mRNA transcripts, including those typically associated with cytosolic proteins, are represented and translated on the ER. By utilizing advanced techniques like ribosome footprinting and high-throughput sequencing, the study aims to uncover the pathways that mediate mRNA localization to the ER and the roles of specific RNA binding proteins in this process. This could lead to a better understanding of protein biogenesis and cellular function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein synthesis disorders or diseases that involve the endoplasmic reticulum.
Not a fit: Patients with conditions unrelated to protein synthesis or the endoplasmic reticulum may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of protein synthesis and regulation, potentially leading to new therapeutic strategies for diseases related to protein misfolding and localization.
How similar studies have performed: While the specific focus on mRNA localization to the ER is relatively novel, previous studies have successfully explored related mechanisms of protein synthesis and localization.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NICCHITTA, CHRISTOPHER V. — DUKE UNIVERSITY
- Study coordinator: NICCHITTA, CHRISTOPHER V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.