Understanding how RNA interacts with proteins in chromatin
Official title: Dissecting modular interaction of RNA with protein in chromatin
Funded at Lieber Institute, INC. · NIH-10695219 · Data updated 2026-11-12
This study is looking at how RNA and certain proteins work together to control gene activity, which could help us understand more about diseases and development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lieber Institute, INC. NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $248,930 |
| NIH project number | 5R00GM137072-04 |
| Project ID | NIH-10695219 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that involve chromatin regulation and gene expression abnormalities.
✕Less likely to help
Patients with conditions unrelated to RNA interactions or chromatin regulation may not benefit from this research.
What this research studies
This research investigates the complex interactions between RNA and chromatin-associated proteins (CAPs) to understand their roles in gene regulation. By examining how different RNA molecules bind to multiple proteins, the study aims to reveal the combinatorial nature of these interactions and their impact on chromatin states. The approach involves detailed molecular analysis to uncover the regulatory networks that RNA participates in, which could have implications for various diseases and developmental processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic targets for diseases linked to chromatin dysfunction.
How similar studies have gone: While the specific combinatorial approach to RNA and CAP interactions is novel, previous studies have shown success in understanding individual RNA-protein interactions.
Where this research is happening
-
Lieber Institute, INC.
Baltimore, United States Active
Researchers
- Principal investigator: Hwang, Taeyoung — Lieber Institute, INC.
- Study coordinator: Hwang, Taeyoung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.