Understanding how RNA interacts with proteins in chromatin
Dissecting modular interaction of RNA with protein in chromatin
['FUNDING_OTHER'] · LIEBER INSTITUTE, INC. · NIH-10695219
This study is looking at how RNA and certain proteins work together to control gene activity, which could help us understand more about diseases and development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LIEBER INSTITUTE, INC. (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10695219 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between RNA and chromatin-associated proteins (CAPs) to understand their roles in gene regulation. By examining how different RNA molecules bind to multiple proteins, the study aims to reveal the combinatorial nature of these interactions and their impact on chromatin states. The approach involves detailed molecular analysis to uncover the regulatory networks that RNA participates in, which could have implications for various diseases and developmental processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases that involve chromatin regulation and gene expression abnormalities.
Not a fit: Patients with conditions unrelated to RNA interactions or chromatin regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic targets for diseases linked to chromatin dysfunction.
How similar studies have performed: While the specific combinatorial approach to RNA and CAP interactions is novel, previous studies have shown success in understanding individual RNA-protein interactions.
Where this research is happening
BALTIMORE, UNITED STATES
- LIEBER INSTITUTE, INC. — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HWANG, TAEYOUNG — LIEBER INSTITUTE, INC.
- Study coordinator: HWANG, TAEYOUNG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.