Understanding how RNA interacts with chromatin to influence cell development
Revealing the RNA foundations of chromatin-based epigenetics
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11045651
This study is looking at how RNA works with DNA to help cells grow and change, using mouse stem cells and tiny creatures like ants and flies, to better understand how our bodies develop and heal.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11045651 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between RNA and chromatin, which are crucial for determining how cells develop and differentiate. By using advanced techniques in biochemistry and functional genomics, the study focuses on mouse embryonic stem cells and model organisms like ants and flies to explore epigenetic memory. The researchers aim to uncover the mechanisms behind RNA's role in regulating gene expression and cell fate transitions, which could lead to new insights in developmental biology and regenerative medicine.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to cellular differentiation or developmental disorders.
Not a fit: Patients with fully developed and differentiated cells, such as those with stable chronic conditions unrelated to cellular differentiation, may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and manipulating cell differentiation, which may benefit patients with regenerative medicine needs.
How similar studies have performed: Previous research has shown promising results in understanding RNA and chromatin interactions, indicating that this approach has the potential for significant advancements in the field.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BONASIO, ROBERTO — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: BONASIO, ROBERTO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.