Understanding how RNA interacts with a bacterial protein to regulate gene expression
Modeling Hfq-RNA Dynamics on an Atomistic Scale
['FUNDING_FELLOWSHIP'] · JOHNS HOPKINS UNIVERSITY · NIH-10998682
This study is looking at how a special protein in bacteria helps tiny RNA molecules connect with their messages, which could help us understand how bacteria react to stress and cause infections, ultimately leading to new ways to fight bacterial illnesses.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10998682 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the Hfq chaperone protein in bacteria, which helps small regulatory RNAs bind to their target messenger RNAs. By using advanced techniques like single molecule Förster resonance energy transfer and nuclear magnetic resonance spectroscopy, the project aims to create a detailed model of how RNA binds and moves on the Hfq protein. This understanding could lead to insights into bacterial responses to stress and virulence, which are crucial for developing new antimicrobial strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bacterial infections or those at risk of developing antibiotic-resistant infections.
Not a fit: Patients with viral infections or non-infectious diseases are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to combat bacterial infections by targeting the mechanisms of gene regulation.
How similar studies have performed: Previous research has shown promising results in understanding RNA-protein interactions, making this approach a continuation of established scientific inquiry.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WHITE, ELISE — JOHNS HOPKINS UNIVERSITY
- Study coordinator: WHITE, ELISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.