Understanding how RNA editing works in brain tumors
Molecular mechanisms that regulate ADAR target recognition and RNA editing in vivo
This study is looking at how certain proteins help enzymes edit RNA, which is important for how genes work, especially in brain tumors, and it hopes to find new ways to treat these conditions that could help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10825154 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms by which RNA binding proteins influence the recognition of RNA targets by ADAR enzymes, which are crucial for RNA editing. By using both a model organism and human brain tumor cell lines, the research aims to uncover how specific adenosines are edited and how this process affects gene expression. Patients may benefit from insights into the role of RNA editing in brain tumors, potentially leading to new therapeutic strategies. The study employs a combination of biochemistry, genomics, and molecular biology techniques to achieve its goals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with brain tumors, particularly glioblastomas.
Not a fit: Patients with non-cancerous conditions or those not affected by brain tumors may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for brain tumors by enhancing our understanding of RNA editing mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding RNA editing mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Hundley, Heather Ann — Trustees of Indiana University
- Study coordinator: Hundley, Heather Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.