Understanding how RNA editing affects cancer
Exploiting public genomic and transcriptomic data to uncover cancer-RNA editing relationships
This study is looking at how a specific change in RNA, called A-to-I editing, might affect cancer and how patients respond to treatment, with the hope of finding new insights that could help improve cancer care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10912535 on NIH RePORTER |
What this research studies
This research investigates the role of RNA editing in cancer by analyzing existing genomic and transcriptomic data. It focuses on a specific type of RNA modification known as adenosine to inosine (A-to-I) editing, which is catalyzed by ADAR enzymes. By utilizing advanced bioinformatics techniques, the project aims to uncover the mechanisms through which RNA editing influences cancer pathways and patient outcomes. This could lead to a better understanding of how RNA alterations affect cancer progression and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who may have alterations in RNA editing that affect their disease.
Not a fit: Patients with non-cancerous conditions or those whose cancer is not influenced by RNA editing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer mechanisms and improve treatment strategies for patients.
How similar studies have performed: Previous research has shown promising results in understanding RNA editing in cancer, indicating that this approach has potential for significant findings.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Xiao, Xinshu Grace — University of California Los Angeles
- Study coordinator: Xiao, Xinshu Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.