Understanding how RNA editing affects brain function and diseases
Systematic approaches to deciphering regulation and function of RNA editing in brain
This study is looking at how a specific change in RNA might affect brain function and contribute to conditions like Alzheimer's and autism, with the hope that understanding these changes can lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10993607 on NIH RePORTER |
What this research studies
This research investigates the role of RNA editing, particularly the conversion of adenosine to inosine, in brain function and its implications for neuropsychiatric diseases like Alzheimer's and autism. By utilizing advanced sequencing technologies and bioinformatics, the project aims to identify and characterize RNA editing sites and their regulatory functions in the brain. The research focuses on understanding how these modifications impact neuronal signaling and may contribute to various brain disorders. Patients may benefit from insights gained into the mechanisms of these diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neuropsychiatric disorders like Alzheimer's disease, autism spectrum disorder, or amyotrophic lateral sclerosis.
Not a fit: Patients without neuropsychiatric disorders or those not affected by RNA editing-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for neuropsychiatric conditions such as Alzheimer's disease and autism.
How similar studies have performed: Previous research has shown promising results in understanding RNA editing's role in brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Xiao, Xinshu Grace — University of California Los Angeles
- Study coordinator: Xiao, Xinshu Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.