Understanding how RNA editing affects brain function and cancer
Molecular mechanisms that regulate ADAR target recognition and RNA editing in vivo
This study is looking at how certain enzymes change RNA in our cells, which can affect brain function and diseases like glioblastoma, to find new ways to improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-10701878 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind RNA editing, a process that alters the genetic information in RNA molecules. By studying how specific enzymes, known as ADARs, recognize and edit RNA, the research aims to uncover how these processes impact normal brain function and contribute to diseases like glioblastoma. The approach includes using various model organisms to observe the effects of RNA editing and its regulators, which could lead to new therapeutic strategies. Patients may benefit from insights into how RNA editing can be targeted to improve treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with glioblastoma or other related neurological disorders.
Not a fit: Patients with conditions unrelated to RNA editing or those not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance RNA editing, potentially improving treatment for brain cancers and other disorders.
How similar studies have performed: Previous research has shown promising results in understanding RNA editing mechanisms, suggesting potential for breakthroughs in treatment strategies.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Hundley, Heather Ann — Trustees of Indiana University
- Study coordinator: Hundley, Heather Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.