Understanding how RNA editing affects brain aging and Alzheimer's disease
Official title: Leveraging large-scale genomics to dissect A-to-I editing in brain aging and Alzheimer's disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11078303 · Data updated 2026-11-12
This study is looking at how changes in a specific type of RNA editing might affect the aging brain and contribute to Alzheimer's disease, helping us understand more about these processes and potentially leading to new ways to study them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $508,112 |
| NIH project number | 5R01AG087324-02 |
| Project ID | NIH-11078303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with early-stage cognitive impairment or those without any signs of dementia may not benefit directly from this research.
What this research studies
This research investigates the role of adenosine-to-inosine (A-to-I) editing in the aging brain and its connection to Alzheimer's disease. By examining how these RNA modifications influence gene function and protein production, the study aims to uncover the mechanisms behind changes in RNA editing as we age and in the context of dementia. The researchers will utilize advanced genomic techniques to analyze RNA samples from brain tissue, focusing on how genetic variations affect RNA editing levels. This comprehensive approach seeks to fill existing knowledge gaps and develop new experimental tools for studying these processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological mechanisms of Alzheimer's disease, potentially paving the way for innovative treatments or preventive strategies.
How similar studies have gone: Previous research has shown promising results in understanding RNA editing's role in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Breen, Michael S — Icahn School of Medicine at Mount Sinai
- Study coordinator: Breen, Michael S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.