Understanding how RNA editing affects brain aging and Alzheimer's disease
Leveraging large-scale genomics to dissect A-to-I editing in brain aging and Alzheimer's disease
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11078303
This study is looking at how changes in a specific type of RNA editing might affect the aging brain and contribute to Alzheimer's disease, helping us understand more about these processes and potentially leading to new ways to study them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11078303 on ClinicalTrials.gov |
What this research studies
This research investigates the role of adenosine-to-inosine (A-to-I) editing in the aging brain and its connection to Alzheimer's disease. By examining how these RNA modifications influence gene function and protein production, the study aims to uncover the mechanisms behind changes in RNA editing as we age and in the context of dementia. The researchers will utilize advanced genomic techniques to analyze RNA samples from brain tissue, focusing on how genetic variations affect RNA editing levels. This comprehensive approach seeks to fill existing knowledge gaps and develop new experimental tools for studying these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with early-stage cognitive impairment or those without any signs of dementia may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological mechanisms of Alzheimer's disease, potentially paving the way for innovative treatments or preventive strategies.
How similar studies have performed: Previous research has shown promising results in understanding RNA editing's role in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BREEN, MICHAEL S — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: BREEN, MICHAEL S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.