Understanding How RNA Controls Our Genes
Biophysical investigations of RNA complexes essential for gene expression
This research explores how tiny RNA molecules and proteins work together to control our genes, which is important for understanding diseases like Alzheimer's and ALS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11080202 on NIH RePORTER |
What this research studies
This project uses advanced methods to study the structure and function of RNA-protein complexes that regulate how genes are turned on and off in our cells. We are looking closely at how these complexes help assemble the spliceosome, a cellular machine that processes genetic instructions, and how they manage the lifespan of messenger RNA. We also explore a new area where special RNA tails can silence genes, a process that might be involved in conditions affecting the brain. This work aims to uncover fundamental processes that go awry in diseases like Alzheimer's and ALS.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually inform future treatments for individuals with neurodegenerative conditions like Alzheimer's disease and ALS.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new targets for therapies by improving our understanding of how gene expression goes wrong in neurological diseases.
How similar studies have performed: While the specific molecular mechanisms being investigated are novel, the broader field of RNA biology has seen significant advancements in understanding gene regulation.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Butcher, Samuel E — University of Wisconsin-Madison
- Study coordinator: Butcher, Samuel E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.