Understanding How RNA Controls Genes and Immunity
Mechanistic Investigation of RNA-Mediated Gene Regulation and Immunity
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11181278
This research explores how tiny molecules called RNA work inside cells, which could help us develop new ways to fight bacterial infections and correct genetic problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11181278 on ClinicalTrials.gov |
What this research studies
Our team is working to understand the precise ways RNA molecules guide proteins and form specific shapes to perform important jobs within cells. We are particularly interested in two areas: how RNA acts as an information carrier, like in CRISPR gene editing, and how RNA structures called riboswitches control bacterial functions. By uncovering these fundamental mechanisms, we hope to lay the groundwork for future medical breakthroughs. This work could lead to new tools for editing genes or developing powerful new antibiotics.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future applications could benefit individuals with bacterial infections or genetic conditions.
Not a fit: Patients without conditions related to bacterial infections or genetic diseases would not directly benefit from this specific basic science research.
Why it matters
Potential benefit: If successful, this work could lead to the development of highly effective new antibiotics to combat bacterial infections and advanced gene-editing technologies for treating genetic diseases.
How similar studies have performed: CRISPR-Cas systems, which are a focus of this work, have already shown remarkable success in gene editing, and riboswitches are a known target for antibiotic development.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KE, AILONG — YALE UNIVERSITY
- Study coordinator: KE, AILONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.