Understanding how RNA controls gene regulation during early development
Official title: Decoding Repression: Recruitment of epigenetic silencers by RNA binding proteins and long non-coding RNAs
Funded at Univ of North Carolina Chapel Hill · NIH-10998888 · Data updated 2026-11-12
This study is exploring how certain RNA molecules help control gene activity during early development, which is important for healthy cell function, and it's designed for anyone interested in learning more about how genes work, especially in relation to the Xist RNA that helps manage one of the X chromosomes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | November 1, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $40,064 |
| NIH project number | 1F31HD114456-01A1 |
| Project ID | NIH-10998888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic or developmental disorders that may be linked to epigenetic regulation.
✕Less likely to help
Patients with conditions unrelated to gene regulation or epigenetic mechanisms may not benefit from this research.
What this research studies
This research investigates the role of long non-coding RNAs (lncRNAs) in regulating gene expression during early development. It focuses on how these lncRNAs recruit epigenetic enzymes to specific genes, which is crucial for proper cell function and development. The project aims to provide training in RNA biology, developmental biology, and computational analysis, ultimately contributing to a deeper understanding of gene regulation mechanisms. By studying the Xist lncRNA, which is known for silencing one of the X chromosomes, the research seeks to uncover the fundamental processes that govern gene expression.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for developmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding lncRNA functions, making this approach a continuation of established findings.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Abrash, Elizabeth — Univ of North Carolina Chapel Hill
- Study coordinator: Abrash, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.