Understanding how RNA controls gene regulation during early development
Decoding Repression: Recruitment of epigenetic silencers by RNA binding proteins and long non-coding RNAs
['FUNDING_FELLOWSHIP'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10998888
This study is exploring how certain RNA molecules help control gene activity during early development, which is important for healthy cell function, and it's designed for anyone interested in learning more about how genes work, especially in relation to the Xist RNA that helps manage one of the X chromosomes.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10998888 on ClinicalTrials.gov |
What this research studies
This research investigates the role of long non-coding RNAs (lncRNAs) in regulating gene expression during early development. It focuses on how these lncRNAs recruit epigenetic enzymes to specific genes, which is crucial for proper cell function and development. The project aims to provide training in RNA biology, developmental biology, and computational analysis, ultimately contributing to a deeper understanding of gene regulation mechanisms. By studying the Xist lncRNA, which is known for silencing one of the X chromosomes, the research seeks to uncover the fundamental processes that govern gene expression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic or developmental disorders that may be linked to epigenetic regulation.
Not a fit: Patients with conditions unrelated to gene regulation or epigenetic mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for developmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding lncRNA functions, making this approach a continuation of established findings.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABRASH, ELIZABETH — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: ABRASH, ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.