Understanding how RNA controls brain function and behavior
Official title: RNA Control of Neural Function
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11014991 · Data updated 2026-11-12
This study is looking at how RNA affects brain function, especially how it helps with learning and memory, and it's for people interested in understanding conditions like autism and Fragile X syndrome, with the hope of finding new ways to help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $714,341 |
| NIH project number | 5R35GM149216-03 |
| Project ID | NIH-11014991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or Fragile X syndrome.
✕Less likely to help
Patients with neurodevelopmental disorders unrelated to RNA regulation may not benefit from this research.
What this research studies
This research investigates how RNA influences neural function, particularly focusing on the control of synaptic plasticity, which is essential for learning and memory. It explores the consequences of mis-regulated RNA translation, which can lead to neurodevelopmental and neurodegenerative disorders. The study employs molecular, electrophysiological, and behavioral experiments to understand the roles of specific RNA-binding proteins in regulating translation and alternative splicing in the brain. By examining these processes, the research aims to uncover mechanisms that could lead to new therapeutic strategies for conditions like autism and Fragile X syndrome.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodevelopmental disorders, improving cognitive function and quality of life for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding RNA's role in neural function, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Richter, Joel D — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Richter, Joel D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.