Understanding how RNA choices affect neuron development
Coordination of alternative exon and 3'UTR choices in mRNAs
This study is looking at how different ways of handling RNA can affect the growth and development of nerve cells, using fruit flies and human stem cells, to help us understand what controls these important processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-11095174 on NIH RePORTER |
What this research studies
This research investigates how different choices in RNA processing, specifically alternative exons and 3' untranslated regions (3'UTRs), influence the development of neurons. Using advanced long-read RNA sequencing technology, the study will explore these interactions at the single-cell level in Drosophila and human embryonic stem cells differentiated into neurons. The goal is to identify the regulatory factors that coordinate these RNA processing events, which are crucial for proper axon growth and neurodevelopment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders or those interested in the genetic and molecular mechanisms underlying neuron development.
Not a fit: Patients with conditions unrelated to neurodevelopment or those not affected by RNA processing mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into neuronal development and potential therapeutic strategies for neurodevelopmental disorders.
How similar studies have performed: Previous research has shown success in understanding RNA processing in model organisms like Drosophila, indicating potential for similar findings in human studies.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Miura, Pedro — University of Connecticut Sch of Med/dnt
- Study coordinator: Miura, Pedro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.