Understanding how RNA chemical modifications are made and recognized
Official title: INVESTIGATE SEQUENCE SPECIFICITY IN THE BIOSYNTHESIS AND RECOGNITION OF RNA CHEMICAL MODIFICATIONS
Funded at Boston College · NIH-10914191 · Data updated 2026-11-12
This study is looking at how tiny chemical changes in RNA can affect how genes work, and it aims to understand how these changes are influenced by things like diet and the environment, which could help develop new treatments for diseases related to gene regulation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston College NIH-funded |
| Lab location | 1 site (Chestnut Hill, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $391,250 |
| NIH project number | 5R35GM150789-02 |
| Project ID | NIH-10914191 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene expression dysregulation, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to RNA modifications or gene expression regulation may not benefit from this research.
What this research studies
This research investigates the specific sequences in RNA that are modified chemically and how these modifications affect gene expression. By utilizing advanced high-throughput sequencing technologies, the study aims to uncover the mechanisms behind the installation of these modifications and their role in protein-RNA interactions. The research focuses on how various factors, such as metabolic signals and environmental changes, influence these modifications. Patients may benefit from insights gained about RNA modifications that could lead to new therapeutic strategies for diseases linked to gene regulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases by targeting RNA modifications that regulate gene expression.
How similar studies have gone: Other research has shown promising results in understanding RNA modifications, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
Boston College
Chestnut Hill, United States Active
Researchers
- Principal investigator: Zhou, Huiqing — Boston College
- Study coordinator: Zhou, Huiqing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.