Understanding how RNA changes in healthy and diseased cells
Revealing the dynamics of RNA metabolism with nucleotide recoding chemistry
This project is developing new ways to watch how RNA, a key molecule in our cells, changes over time in both healthy cells and those affected by diseases like leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11193876 on NIH RePORTER |
What this research studies
Our cells constantly adjust their RNA levels, but current methods only offer a single snapshot, making it hard to see how these changes happen. This project aims to create a new technology that can track RNA changes over time, giving us a dynamic view instead of a static one. By improving chemical methods, we can better understand how gene expression is controlled and how diseases and treatments affect these processes. This deeper understanding could help us find new ways to diagnose and treat conditions where RNA changes play a role.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but it aims to benefit those with conditions where RNA metabolism is disrupted, such as acute megakaryoblastic leukemia.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how diseases like leukemia develop and respond to treatments, potentially opening doors for new diagnostic tools and therapies.
How similar studies have performed: Previous work supported by this grant has already led to improved chemical methods and open-source software for studying RNA dynamics.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Simon, Matthew David — Yale University
- Study coordinator: Simon, Matthew David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.