Understanding how RNA changes affect gene control
Investigating the roles of nuclear RNA modifications in gene regulation
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA RIVERSIDE · NIH-11159451
This research explores how tiny changes to RNA molecules inside our cells influence how our genes work, which could help us understand diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA RIVERSIDE (nih funded) |
| Locations | 1 site (RIVERSIDE, UNITED STATES) |
| Trial ID | NIH-11159451 on ClinicalTrials.gov |
What this research studies
Our genes give instructions for making proteins, and RNA molecules help carry out these instructions. This project looks at how small chemical changes, called modifications, on RNA can change how genes are turned on or off. These modifications are important for normal body functions and are also linked to the development of human diseases, including various cancers, viral infections, and neurodegenerative conditions. We are particularly interested in specific modifications on the ends of RNA molecules and how they might be altered to affect cell processes and disease progression.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit those affected by cancers, viral infections, and neurodegenerative diseases in the long term.
Not a fit: Patients not affected by cancers, viral infections, or neurodegenerative diseases may not directly benefit from this specific area of research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how diseases like cancer develop and potentially open new avenues for future treatments.
How similar studies have performed: Recent advancements in sequencing technology and studies by this research team and others have shown the broad importance of RNA modifications, though the specific alternative modifications of the 5' triphosphate group remain a knowledge gap.
Where this research is happening
RIVERSIDE, UNITED STATES
- UNIVERSITY OF CALIFORNIA RIVERSIDE — RIVERSIDE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GU, WEIFENG — UNIVERSITY OF CALIFORNIA RIVERSIDE
- Study coordinator: GU, WEIFENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers