Understanding how RNA changes affect cancer
Exploiting public genomic and transcriptomic data to uncover cancer-RNA editing relationships
This project looks at existing genetic information to learn more about how changes in RNA, called RNA editing, are connected to different types of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11126026 on NIH RePORTER |
What this research studies
Our bodies' genetic instructions are stored in DNA, which then makes RNA, a messenger molecule. Sometimes, these RNA messages get altered in a process called RNA editing, which can change how our cells function. This project aims to understand why these RNA changes happen in cancer and how they contribute to the disease. By looking closely at large amounts of existing genetic data from cancer patients, we hope to uncover new ways that RNA editing influences cancer development and progression. This deeper understanding could help us find new targets for future cancer treatments.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit patients with various types of cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this specific data analysis project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of cancer biology and potentially identify new targets for developing future cancer therapies.
How similar studies have performed: Previous research has identified some critical RNA editing sites in cancer-related genes, and widespread abnormal RNA editing has been reported in many cancer types.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Xiao, Xinshu Grace — University of California Los Angeles
- Study coordinator: Xiao, Xinshu Grace
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.