Understanding how RNA-binding proteins affect fertility
Investigating the molecular functions and mechanisms of RNA-binding proteins crucial for gametogenesis
This study is looking at how certain proteins that bind to RNA help in the development of sperm and eggs, which is important for fertility, and it aims to find out how changes in these proteins might cause infertility, using fruit flies to learn more about how they work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11087505 on NIH RePORTER |
What this research studies
This research investigates the role of RNA-binding proteins (RBPs) in gametogenesis, which is crucial for fertility. It focuses on identifying and understanding the molecular functions of specific RBPs that regulate gene expression during the development of sperm and eggs. By studying these proteins, the research aims to uncover how mutations in RBPs can lead to infertility. The approach includes genetic studies in model organisms like Drosophila to reveal the mechanisms by which these proteins operate.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples experiencing infertility due to unknown genetic causes.
Not a fit: Patients whose infertility is due to non-genetic factors or those who have already identified the cause of their infertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for infertility caused by genetic factors.
How similar studies have performed: Other research has shown success in understanding the role of RBPs in fertility, but this study aims to explore novel RBPs that have not been previously characterized.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Fukunaga, Ryuya — Johns Hopkins University
- Study coordinator: Fukunaga, Ryuya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.