Understanding how RNA binding proteins affect cancer growth and patient outcomes
Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival
This study is looking at how certain proteins that bind to RNA might affect cancer growth and how long patients live, with the hope of finding new ways to help treat cancer by understanding these proteins better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11055314 on NIH RePORTER |
What this research studies
This research investigates the role of RNA binding proteins (RBPs) in cancer progression and patient survival. By analyzing data from cancer patients, the study aims to identify specific RBPs that are dysregulated in tumors compared to normal tissues. The researchers will use advanced computational methods to discover RNA motifs that these proteins bind to, which may influence cancer development and metastasis. Ultimately, the goal is to develop a framework that links the expression of these RBPs to patient survival rates, providing insights into their potential as therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with various types of cancer, particularly those showing signs of tumor progression.
Not a fit: Patients with non-cancerous conditions or those whose tumors do not exhibit dysregulation of RNA binding proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for predicting cancer progression and improving patient survival through targeted therapies.
How similar studies have performed: Previous research has indicated that targeting RNA binding proteins can influence cancer outcomes, suggesting that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Tavazoie, Saeed F — Columbia University Health Sciences
- Study coordinator: Tavazoie, Saeed F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.