Understanding how RNA and proteins work together to keep our genes healthy
Official title: Structural transitions and RNA-mediated mechanisms of LSD1
Funded at Marquette University · NIH-11145023 · Data updated 2026-11-12
This project explores how special RNA molecules interact with proteins to maintain the stability of our genetic material, which is important for healthy aging and preventing diseases like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marquette University NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 15, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $416,197 |
| NIH project number | 5R01GM120572-09 |
| Project ID | NIH-11145023 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not directly involve patient participation at this stage, but future studies building on this knowledge may seek individuals with conditions related to aging, cancer, or neurological disorders.
✕Less likely to help
Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science project.
What this research studies
Our bodies rely on a complex interplay between RNA and proteins to keep our genes stable and functioning correctly. This research looks at how non-coding RNAs, which don't make proteins themselves, connect with proteins that are part of our DNA structure. These connections are vital for how our genes are organized and expressed, and problems in this process are linked to aging, the spread of cancer, and brain development. We want to understand the specific features that guide these RNA-protein interactions and how changes in these interactions affect important proteins that modify our DNA.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the fundamental processes that contribute to aging, cancer, and neurological conditions, potentially opening doors for new treatments.
How similar studies have gone: While the broad area of RNA-protein interactions is well-studied, this project focuses on specific structural transitions and mechanisms of the LSD1 enzyme, representing a novel and detailed approach.
Where this research is happening
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Marquette University
Milwaukee, United States Active
Researchers
- Principal investigator: Reiter, Nicholas J — Marquette University
- Study coordinator: Reiter, Nicholas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.