Understanding how RNA and proteins interact in a parasite's telomerase
Decoding RNA-Protein Interactions in Trypanosoma Telomerase
This study is looking at how a specific enzyme in a parasite that can cause long-term infections in people works, focusing on the relationship between its RNA and proteins, which could help find new ways to fight off these infections.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project ID | NIH-10515146 on NIH RePORTER |
What this research studies
This research investigates the interactions between RNA and proteins in the telomerase enzyme of Trypanosoma brucei, a parasite that can cause long-term infections in humans. By studying how RNA folds and binds to proteins, the researchers aim to uncover mechanisms that regulate telomere replication, which is crucial for the parasite's survival and ability to evade the immune system. The approach involves analyzing the unique structural features of telomerase RNA in this organism compared to other species. Insights gained from this research could lead to new strategies for controlling infections caused by this parasite.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with Trypanosoma brucei or those at risk of such infections.
Not a fit: Patients who are not infected with Trypanosoma brucei or do not have a related condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that disrupt the parasite's ability to survive and cause disease.
How similar studies have performed: Other research has shown success in understanding telomerase mechanisms in different organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlotte, United States
- University of North Carolina Charlotte — Charlotte, United States (Active)
Researchers
- Principal investigator: Chakrabarti, Kausik — University of North Carolina Charlotte
- Study coordinator: Chakrabarti, Kausik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.