Understanding how right ventricular failure develops in pulmonary hypertension
Investigating the molecular mechanisms of right ventricular failure in pulmonary hypertension
This study is looking at how high blood pressure in the lungs can lead to problems in the right side of the heart, and it's trying to find new ways to help people with heart issues caused by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10894173 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that lead to right ventricular failure (RVF) as a result of pulmonary hypertension (PH). It focuses on the processes of remodeling and fibrosis in the heart's right ventricle, which are critical for understanding the disease's progression. Using advanced RNA sequencing techniques on pre-clinical rat models, the study aims to identify specific pathways and molecular targets that could be addressed with new therapies. By exploring the role of certain proteins and genetic factors, the research seeks to uncover potential treatment strategies for patients suffering from RVF due to PH.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pulmonary hypertension who are at risk of developing right ventricular failure.
Not a fit: Patients with right ventricular failure not caused by pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the failing right ventricle in patients with pulmonary hypertension.
How similar studies have performed: Other research has shown promise in targeting molecular mechanisms in heart failure, suggesting that this approach could lead to significant advancements.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Umar, Soban — University of California Los Angeles
- Study coordinator: Umar, Soban
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.