Understanding how Rift Valley Fever Virus infects and causes disease
Identification and Characterization of Entry Factors Critical for Rift Valley Fever Virus Infection and Pathogenesis
This study is looking at how the Rift Valley Fever Virus infects people and causes illness, with the goal of finding ways to create better treatments and vaccines, especially since this virus could show up in new places like the United States.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11040296 on NIH RePORTER |
What this research studies
This research focuses on identifying and characterizing the factors that allow the Rift Valley Fever Virus (RVFV) to infect hosts and cause disease. By studying the virus's interaction with host cells, the research aims to uncover critical entry points and mechanisms of pathogenesis. This knowledge could lead to the development of effective antiviral treatments and vaccines. The research is particularly relevant given the virus's potential to emerge in non-endemic regions, including the United States.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals living in or traveling to regions where Rift Valley Fever is endemic, particularly in sub-Saharan Africa.
Not a fit: Patients who do not reside in or travel to areas affected by Rift Valley Fever may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments and vaccines for Rift Valley Fever, improving health outcomes for affected populations.
How similar studies have performed: Other research on emerging infectious diseases has shown success in identifying viral entry mechanisms and developing antiviral therapies, indicating that this approach has potential.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Amarasinghe, Gaya K. — Washington University
- Study coordinator: Amarasinghe, Gaya K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.